Hosted by George Lyall-Brookes, PhD researcher at the University of Liverpool and AMLearn user.
In this insightful session, George walks through how he combined flow chemistry with algorithmic optimisation using AMLearn to push the boundaries of aromatic bromination, covering:
– How a traditional batch aromatic bromination process was translated into continuous flow, enabling access to expanded reaction conditions and chemical space.
– The use of algorithmic optimisation to efficiently identify high-yielding reaction conditions using AMLearn
– The development of both heat-activated and UV-activated bromination pathways, without catalysts or strong acids.
– Mechanistic and kinetic insights that clarify the underlying reaction pathway.
– Application of the developed method across a broader range of aromatic substrates to demonstrate the versatility of the procedure.
This is a must-watch for chemists, process engineers, and innovators exploring the future of autonomous, scalable synthesis.